science

Investing in the climate

Martin Thibodeau, RBC’s B.C. region president, will be honoured at the Ben-Gurion University Gala Dinner June 14. (photo from RBC)

On June 9, Ben-Gurion University president Daniel Chamovitz and members of the Canadian Associates of Ben-Gurion University (CABGU) will visit Vancouver to recognize the launch of its new School of Sustainability and Climate Change (SSCC) and the local supporters who have helped make its opening possible. In particular, Royal Bank of Canada and Martin Thibodeau, RBC’s B.C. region president, will be honoured at the event.

SSCC opened last October at BGU’s Be’er Sheva campus, where its growth has been rapid. Seven months old, the school currently offers two undergraduate degrees and four graduate-level environmental science-related degrees. Its two graduate fellowships, which have supported work in renewable energy and smart city design, were funded by RBC.

“The RBC Research Fund at BGU’s School of Sustainability and Climate Change [is] being established in Martin’s honour, [and] will enable undergraduate and graduate students to be trained as, and pursue meaningful careers as, climate change innovators, entrepreneurs and policy experts,” said David Berson, who serves as CABGU’s executive director for the B.C. and Alberta Region. The funding that is raised at the gala will help further SSCC’s research programs.

SSCC’s mandate isn’t just to address environmental concerns at home in Israel, said Chamovitz. It will have a global reach, as well. BGU is currently working to cement research partnerships with universities and countries that have similar interests in addressing climate challenges. Chamovitz said RBC’s investment in its new school will provide a pathway to meeting that global need.

“RBC was one of the early supporters of SSCC, and this support was essential for leveraging subsequent support,” he said. “The Royal Bank of Canada believes in us,” and that support has served as an encouraging model for other companies to invest in BGU’s programs as well, he said.

Lorne Segal, president of Kingswood Properties and director of the Vancouver Board of Trade, who is an honorary co-chair of the June event with his wife, Mélita Segal, said corporate sponsorship is crucial to startup programs like SSCC. He said corporate support is also vital to finding answers to environmental challenges like global warming.

“Sponsorship from leading businesses and industry leaders does provide imaginative solutions to complex issues impacting our people and the planet,” he said. “Without significant and generous sponsorship support, this crucial work, simply put, would not be possible.”

Segal said supporting initiatives that bring about positive change is part of Thibodeau’s nature.

“Martin Thibodeau truly is a lifelong builder of community,” said Segal. “He is deeply praised by Ben-Gurion University for his commitment to the cause of finding solutions to climate change. It is truly remarkable how much he and RBC Royal Bank have done to enhance the capacity of the Ben-Gurion University community programs and agencies, and advance the conversation on Canada’s transition to a net-zero economy.”

Thibodeau’s support of Canadian Jewish communities and of Israel goes back decades. Originally from Quebec, he served as RBC’s regional president in Montreal until he moved to Vancouver. He oversees some of the largest – and smallest – branches and more than 4,000 employees.

In 2015, while working in Montreal, Thibodeau volunteered as a co-chair for Quebec’s largest multi-day walk for women’s cancers, held by Pharmaprix, to raise money for research at the Jewish General Hospital. “I have been involved with the Jewish community for almost my entire RBC career,” he told the Independent.

He is a strong supporter of the Jewish Federation of Greater Vancouver and the Jewish Community Centre of Greater Vancouver and their community initiatives, and he has been to Israel several times. It was in 2014, said Thibodeau, that he and his wife, Caroline, visited Be’er Sheva and learned of BGU’s environmental research. “[I was] so inspired by the research [and] the innovation,” he said, noting that it wasn’t hard to get behind the creation of a school that was working to find solutions to climate concerns.

“It’s right there in front of me every day,” he said. “I am a proud father of three children and I believe we have a responsibility to make sure that our climate can continue to thrive, and well beyond my lifetime. It is my personal belief that we need to do that today more than ever.”

Thibodeau said it’s been an interesting journey since that first visit to BGU in 2014. “It’s become such a tough priority for the world,” he said of climate change. In Canada, among other things, he supported RBC’s Blue Water Project, which helped provide clean water access to Canadian communities.

Still, Thibodeau is a reticent honouree. He admits that he is uncomfortable with the idea that he will be the guest of honour at a gala, even if it is for a cause he loves. “I’m very humbled,” he said. “I don’t like to have that kind of spotlight on me.” But, he said, raising money for research that might one day create a safer and better environment, that is something he will gladly get behind.

photo - Mélita and Lorne Segal, honorary chairs of the BGU Gala Dinner for Sustainability and Climate Change — Mélita and Lorne Segal, honorary chairs of the BGU Gala Dinner for Sustainability and Climate Change. *(photo by The Collective You)*

The gala will also acknowledge Lorne and Mélita Segal, who are well-known for their philanthropy and other work. Both have been recognized by Capilano University with honorary doctor of letters, and Lorne Segal has a doctor of laws (hon.) from the Justice Institute of British Columbia. He was inducted into the Order of British Columbia for his work as founding chair of Free the Children’s WE Day Vancouver and as chair of the Coast Mental Health Courage to Come Back Awards. The Segals regularly open their home to fundraising galas.

“When Lorne and I built our home, we didn’t really do it for ourselves but, rather, to share it with the community,” said Mélita Segal. “Whether it was Dr. Peter AIDS Foundation, Arts Umbrella, Chor Leoni, JNF [Jewish National Fund] or WE Charity … it has been a great joy for us and very fulfilling to give back and share in this way.”

Berson described the Segals as “tireless builders of community, leading by example while creating opportunities for people in the business world to make a difference in the lives of others. Ben-Gurion University, Canada, is genuinely fortunate to have their leadership for this event and for our organization.”

The Ben-Gurion Sustainability and Climate Change Gala on June 9 takes place at Fairmont Pacific Rim. Tickets and tables can be purchased at bengurion.ca/vancouver-gala-2022-tickets or by contacting Berson at [email protected].

Jan Lee is an award-winning editorial writer whose articles and op-eds have been published in B’nai B’rith Magazine, Voices of Conservative and Masorti Judaism and Baltimore Jewish Times, as well as a number of business, environmental and travel publications. Her blog can be found at multiculturaljew.polestarpassages.com.

The scarcity of water

The seawater desalination plant in Ashkelon, Israel. (photo from © VID)

The Consulate General of Israel in Toronto and Western Canada marked World Water Day on March 22 with a webinar entitled “Squeezing Water from a Stone.” Dr. Alex Furman of Technion – Israel Institute of Technology in Haifa and Dr. Roy Brouwer of the University of Waterloo focused on Israeli and Canadian perspectives of water conservation and management.

Furman, director of the Stephen and Nancy Grand Water Research Institute at Technion, provided an overview of water management in Israel, describing how a land that is 60% desert – and uses more than 100% of its water – still has water left for use.

“The issue of water scarcity in the future is going to grow as the population grows and we need more water to feed people and for agriculture,” Furman said.

Israel’s population, which has expanded tenfold in the past 75 years, continues to climb. Further, its Western standard of living, including such things as daily showers, presents a further strain on the country’s water supply.

Israel recognized the need for innovation in this area several decades ago. Starting in the 1980s, it began treating wastewater for reuse in agriculture and, in the 2000s, the country started major desalination projects. Desalinated water now constitutes a large amount of the water consumed in Israel, but is not a completely win-win scenario. For example, a detrimental consequence of desalination is that the process also removes essential minerals, such as magnesium.

Another area where Israel is taking the lead is in water-saving technology, such as drip irrigation. Agricultural use of water in Israel has decreased in the past 30 years, a period over which agricultural production increased.

“Instead of irrigating the land, we irrigate the plant. Drip irrigation is providing water for what the plant needs. It’s not the amount of water that is important but the precision in how water is applied,” Furman said.

Concurrently, Furman added, Israelis are doing more to reduce water usage in the home, and the country has developed educational campaigns to inform its citizenry on ways to minimize water consumption.

“We are a very fast-growing country that requires a lot of water and requires the development of new water resources at all times,” Furman said.

Brouwer, an economics professor with an academic interest in water resources, highlighted the broader need for collective international partnership in looking at solutions for water issues through interdisciplinary cooperation, policy expertise and innovation.

“Water disregards boundaries and so must we,” he said, employing the motto of his department at the University of Waterloo.

The working definitions of water security, as put forward by the United Nations, Brouwer explained, are to have stable, peaceful and reliable access to adequate quantities and acceptable quality water. This, in turn, should sustain livelihoods, human well-being, socioeconomic development, protection from pollution and other water disasters, and preservation of ecosystems.

“From an economic point of view,” he said, “we need water to produce all kinds of things.”

As examples, Brouwer showed how much water is needed for basic clothing items: 10,000 litres of water are used to produce a kilogram of cotton, which, therefore, means 2,500 litres are required to make a 250-gram T-shirt and 8,000 litres for an 800-gram pair of blue jeans. For a morning cup of coffee, the equivalent of 1,000 cups of water are needed – from growing the bean, processing it and transporting it to the consumer.

Pressures on the international water supply are further exacerbated as countries such as China, Brazil and India achieve a higher standard of living and demand more goods like Western clothing and coffee.

“We expect that water stress will continue into the future,” Brouwer said, noting that two billion people in the world currently live in areas where water is scarce, including in the Middle East and in Northern Africa.

Global demand for water is, according to Brouwer, expected to grow one percent per year until 2050. By that time, 45% of global output would come from countries experiencing water scarcity. Tel Aviv, along with Sao Paulo, Cape Town and Karachi, is among the cities in the world most at risk of experiencing water shortages.

In a chart, Brouwer showed the skewed distribution of water usage around the world – from the average American, who uses 156 gallons per day to a French person who uses 76, an Indian at 38 and a Malian at three. Canada is the second-largest consumer of water per capita in the world. The average Israeli consumes 40% less water than their Canadian counterpart.

In his final remarks, Brouwer said the widely held view of water abundance in Canada may be a misperception when water quality and access to clean and safe drinking water are taken into consideration.

He concluded that water has value, but that its price is not reflective of its true value. Attention, he said, should be paid to both increasing water supply and policies that reduce water demand, and that water pricing is one way to raise awareness for essential water services.

Technion Canada partnered with the consulate on the World Water Day initiative.

Sam Margolis has written for the Globe and Mail, the National Post, UPI and MSNBC.

BGU tackles climate change

Researchers at Ben-Gurion University of the Negev’s School of Sustainability and Climate Change have been experimenting with alternative ways of irrigating trees, in this case, by floodwater. (photo by Dani Machlis/BGU)

“It is in the Negev that the creativity and pioneer vigour of Israel shall be tested,” David Ben-Gurion, Israel’s first prime minister, predicted in 1955.

The country was not even a decade old. Ben-Gurion was trying to inspire a growing population of immigrants, including Holocaust survivors, to realize their collective potential – to not just embrace a new home, but to build a new, resilient future. That legacy, he maintained, would be found in the most unlikely of places: in the harsh expanse of the country’s southern water-poor and undeveloped desert. But their hard work, he insisted, could one day transform Israel.

“In order to be a realist, you must believe in miracles,” he said.

Today, his vision for the Negev lives on at the university that was founded in his name. Ben-Gurion University of the Negev sits, not coincidentally, at the northern tip of the desert. Some 13,000 square kilometres of semi-arid, rocky terrain make up the Negev, punctuated by dry riverbeds and desolate vistas. It’s on the cusp of this wilderness that Israel’s first School of Sustainability and Climate Change (SSCC) was established last October.

This June, Canadian Associates of Ben-Gurion University of the Negev will be holding a gala dinner in Vancouver to raise funds for the SSCC’s ongoing research. Co-chaired by Melita and Lorne Segal, the event will honour Royal Bank of Canada’s B.C. regional president, Martin Thibodeau, for his community-building efforts.

Existential research

According to BGU president Daniel Chamovitz, environmental research has always been a part of BGU’s mission. Water reclamation, sustainable food production and creating plant species that can survive in adverse environmental conditions have been continuing themes of study since the university’s inception in 1969. Establishing a school that could serve as an umbrella for diverse areas of climate and sustainability research was a natural progression.

“We are the engine, by necessity, of development and change in the Negev,” Chamovitz said. That existential motivation has not only led to new ways to desalinate sea water for industrial purposes and engineer new foods, but new collaborative opportunities with countries experiencing climate impacts. The university is home to three campuses that house climate- and sustainability-related studies, as well as a business park with more than 70 multinational companies. It’s also become fertile ground for Israel’s start-up industry and research collaboration.

Chamovitz said countries like the United Arab Emirates (UAE) and Morocco are looking to partner to solve common environmental challenges. Desertification, the erosion of arable lands driven by a changing climate and urbanization, now affects more than one-sixth of the world’s population. There are also real-time challenges in the Middle East, where dry lands predominate but research experience may be limited.

“The Abraham Accords here have been essential for the growth of the school,” said Chamovitz. It’s not only opened doors for political alliances, it’s fostered new research partnerships for institutions like BGU, he said.

“For 50 years, we have been learning to live in our desert,” he added, noting that what was once seen in Israel as a hyper-local challenge – how to live in a desert – has become a concern for an increasing number of countries.

This month, a delegation from Morocco’s Mohammed VI Polytechnic University (UM6P) arrived in Israel to discuss a new research partnership with the university. The collaboration, which will focus broadly on addressing food insecurity, demands for smart agriculture and alternative energy options, will also lead to educational partnerships with UM6P. “They are very excited,” Chamovitz said. “We already have our first students [from Morocco].”

But international collaboration isn’t the only byproduct of the SSCC. There’s growing interest within Israel, as well.

“[The] school has become the magic dust which influences everything,” Chamovitz said, noting that departments and researchers without any seeming connection to climate change and sustainability are identifying ways to explore environmental subjects.

“One of the most surprising and fulfilling outcomes,” he said, “is that our department of Hebrew literature.… That’s when we knew we had succeeded – when Hebrew literature became part of the school.”

Prof. Noam Weisbrod, who directs SSCC’s Jacob Blaustein Institutes for Desert Research, estimates that about 70% of BGU desert research, in one way or another, touches on topics related to climate change and sustainability. The list of departments is diverse, ranging from biology and medical sciences, to environmental geography and earth sciences.

“The idea is to team up and create a force which is focusing on climate change and sustainability and their impacts in different angles and different directions, and to enable multidisciplinary research” that attracts students who can lead the next generation of research into sustainable ways to combat climate change, Weisbrod said.

Mitigation imperative

In February of this year, the International Panel on Climate Change released its sixth report: Climate Change 2022: Impacts, Adaptation and Vulnerability.

“Approximately 3.3 to 3.6 billion people live in contexts that are highly vulnerable to climate change,” the IPCC stated, noting that “current unsustainable development patterns are increasing exposure of ecosystems and people to climate hazards.”

“Diminishing resources is a real challenge,” said Weisbrod, adding that the solutions may lie in how we manage those precious resources. “There is a lot of research on how to get more crop for drop of water. I like that sentence, ‘more crop for drop,’ because this is what we’re trying to do – to get the maximum crop for minimum resources,” he said.

The latest IPCC report suggests humanity is on the right path. Countries like the United Arab Emirates are taking action to protect water resources and reduce climate change impacts like desertification, steps that are part of BGU’s cooperative strategies with UAE.

According to Chamovitz, many of these advances wouldn’t be possible without investors that are willing to support sustainability initiatives. He noted that RBC was one of the SSCC’s first donors and has been important to the school’s success – in 2020, RBC, British Columbia, sponsored the first two research fellowships at SSCC.

Chamovitz will be a special guest at the Ben-Gurion University Gala Dinner for Sustainability and Climate Change on June 9 at Fairmont Pacific Rim. Tickets for the event are available from bengurion.ca/vancouver-gala-2022.

Studying social sense

Michael Gliksberg, left, and Prof. Gil Levkowitz are among the researchers who have discovered that oxytocin in a developing zebrafish brain determines later social behaviour. (photo from Weizmann Institute)

Whenever we decide to throw a party, invite in-laws to dinner or embark on a cruise, we are driven by the most basic component of social behaviour: the desire to hang out with other humans. Considering that the drive to form groups with members of one’s own species has been conserved throughout evolution, it’s evident that social behaviour is governed by genes, at least to some degree. But our parents and teachers help us hone our social graces, so teasing apart the effects of nature and nurture on this behaviour is hard, if not impossible. By studying zebrafish, Weizmann Institute of Science researchers, in collaboration with scientists in Portugal, have managed to solve part of the riddle of how social behaviour is hardwired into the developing brain.

Zebrafish are perfect for studying the inborn basis of behaviour because they receive zero nurturing from parents. “Some fish species take care of their young, but not zebrafish,” explained Prof. Gil Levkowitz of the Weizmann Institute’s molecular cell biology and molecular neuroscience departments, who headed the research team together with Prof. Rui F. Oliveira of Instituto Gulbenkian de Ciência in Portugal. “The female zebrafish spawns several hundred eggs, which are fertilized by sperm released into the water by the male. She does provide her offspring with a ‘lunchbox’ – a protein sac, or yolk, that makes up part of the egg – but, otherwise, her message to her children is: manage on your own.”

At about four weeks of age, the centimetre-long juvenile fish, just out of the larval stage, begin to socialize. Though not as exquisitely synchronized as the schools of moonfish in the movie Finding Nemo, they do exhibit a strong tendency to swim together as a group, termed a shoal. Much like humans, they have an incentive to seek company; in their case, the group provides them with advantages in searching for food, overcoming currents, avoiding predators and finding mates. The shoaling behaviour of zebrafish requires sophisticated processing of visual and social cues, very similar to that which takes place in the brains of socializing humans. In particular, the zebrafish must be able to identify other fish as belonging to their own, “friendly” – as opposed to different or, worse yet, predatory – species.

To learn how the social behaviour of zebrafish develops, the researchers focused on the hormone oxytocin, one of the most important neurochemicals known to enhance social interactions, including bonding. Postdoctoral fellow Dr. Ana Rita Nunes and doctoral student Michael Gliksberg created a system for exploring the effects of oxytocin on the developing brains of zebrafish larvae. They produced transgenic larvae whose oxytocin-making neurons harboured a bacterial gene encoding fatal sensitivity to antibiotics. The researchers could then eliminate these neurons from the brains of the larvae at different stages of their development by adding antibiotics to the water, and they later observed the zebrafish behaviour as they became adults.

The scientists discovered that the larvae whose brains lacked oxytocin early on – specifically, in the first two weeks of life – grew into adult fish with an impaired capacity for social interaction, namely, swimming in a shoal. Although their brains regenerated the oxytocin neurons later in life, this capacity was not restored. This meant that, for adults to be capable of social behaviour, their brains had to be organized by oxytocin in a certain manner during a critical time window of brain development in which the social traits are established.

The researchers further discovered the mechanisms by which oxytocin primes the growing brain for socializing. They showed that oxytocin-producing neurons were critical to the birth of another type of neuron, one that releases the neurotransmitter dopamine, which is known to regulate feelings of reward and motivation. Zebrafish whose brains had not been exposed to oxytocin during the first two weeks of life had reduced numbers of dopamine-making neurons, as well as a reduced number of connections to these neurons, in two distinct brain areas.

One of these areas was responsible for processing visual stimuli, apparently of the kind essential for recognizing potential swimming partners. An analogous area in the brains of mammals, including humans, is involved in processing visual cues in social situations. It controls eye movements that scan, for example, different elements of the face in a particular order to decipher facial expressions. This pattern is often absent in people with autism, suggesting that their brains respond to social-based visual cues differently.

The other dopamine-deficient brain area in the zebrafish was analogous to a major reward centre in the mammalian brain, which is involved in the positive reinforcement of social interactions.

A lack of oxytocin in the critical early developmental period also disrupted a system of neuronal connections known as the social decision-making network – a group of brain areas that work together to process social information. In fish whose brains had developed without oxytocin, the synchronization patterns of neuronal activities among these centres were completely different from those of regular fish.

Nunes summarized: “Oxytocin organizes the developing brain in a way that’s essential for responding to social situations.”

– Courtesy Weizmann Institute

mRNA & cancer drugs

Prof. Etta Livneh (photo by Shay Shmueli/BGU)

Most everyone on the planet has now heard of mRNA, thanks to the vaccines against COVID-19 from Pfizer and Moderna, which are based on messenger RNA. But, before mRNA was used to address COVID, research was conducted into how it could fight cancer. Now, researchers at Ben-Gurion University of the Negev have discovered a key connection between mRNA, peptide proteins and tumour progression.

Messenger RNA codes for different proteins, each with a unique function. There are both “long” and “short” peptides. Until now, scientists were not sure if short peptides had any biological function.

Prof. Etta Livneh of BGU’s Shraga Segal Department of Immunology, Microbiology and Genetics has shown that single short peptides in fact have a very important role – as a kinase inhibitor that can slow tumour growth and invasion, cancer cell survival and metastasis.

Proteins (and protein kinases in particular) propagate signals that carry instructions to the cells and dictate cell fate. There are more than 500 different kinases in the human body.

With cancer, a kinase erroneously tells the cells to divide and reproduce in a rapid and uncontrollable manner. But the flipside is also true: if a kinase can be inhibited, it should block the proliferation of cancer cells.

And that’s “just the tip of the iceberg,” said Livneh, whose discovery has been a decade in the making. “Now that we know that at least some peptides have a biological function, we can begin to discover the roles of many more.”

Kinase inhibitors are already one of the hottest areas of cancer research, in some cases replacing chemotherapy. Livneh’s research will allow scientists to better understand how to control this cancer-fighting technology.

The research was supported by a grant from the Israel Science Foundation and published in PNAS (Proceedings of the National Academy of Sciences of the United States of America).

Israel21c is a nonprofit educational foundation with a mission to focus media and public attention on the 21st-century Israel that exists beyond the conflict. For more, or to donate, visit israel21c.org.

Community milestones … Goldschmidt, Mines, BGU & Weizmann Institute

A German translation of the Talmud, and the first translation of the book ever completed by a single person, is now available on Sefaria, a free nonprofit online library of Jewish texts. The translation by scholar Lazarus Goldschmidt was the first German translation of the Talmud and was released in 1935. While it is used in German Jewish studies departments and universities, it had not been widely accessible to the general public until now.

screenshot - Penny Goldsmith — *(screenshot)*

A celebration of the release took place virtually on Oct. 24. One of the speakers was Penny Goldsmith, Goldschmidt’s eldest granddaughter. Goldsmith is a longtime anti-poverty community worker in Vancouver, and owns a small independent publishing company, Lazara Press, named after her grandfather, who died a few months before she was born. She spoke of her grandfather’s books, “beautiful typographical masterpieces.”

“Grandfather was a type and book designer,” she said. Among his books were literature and poetry, including a collection of poetry he wrote in his early 20s, in Hebrew, “a very unusual choice,” Goldsmith noted, “as Hebrew at that time was reserved for religious study only.”

Goldschmidt was a scholar of Near Eastern languages and, in addition to the Talmud, he translated other religious texts, including a Hebrew translation of the Ethiopic Book of Enoch and a German translation of the Koran. Born in Lithuania, he learned German at the age of 18. His translation of the Talmud took 39 years to complete and he continued to make revisions after publication. He was also a collector of rare books and his extensive collection is now part of the Royal Library in Copenhagen.

After the Goldschmidt Talmud translation became public domain in January 2021, a team of four led by Igor Itkin, a rabbinical student at Rabbinerseminar zu Berlin, integrated its 9,434 pages of text into Sefaria’s free online library. The team’s work included manually linking sections of the translation to corresponding Talmud texts in English and Hebrew/Aramaic already in the Sefaria library. The connections allow scholars, educators and others to navigate between the translations and connect them to the larger library of Jewish scholarship. The team’s work was supported by a grant from the Rothschild Foundation Hanadiv Europe.

***

The Rivals and Other Stories by Jonah Rosenfeld, translated from the Yiddish by Vancouver’s Rachel Mines – who recently retired from Langara College’s English department – has been selected by the Yiddish Book Centre as one of its picks for the 2022 Great Jewish Books Club. The book is available through the Yiddish Book Centre’s store and other online booksellers, including its publisher, Syracuse University Press, which is offering The Rivals at a 50% discount until Dec 1, 2021 (press.syr.edu).

Rosenfeld was a prolific and popular writer from the early 1900s until his death in 1944. Although his writing received critical praise, very little was translated into English until the publication of The Rivals. His stories foreground social anxiety, cultural dislocation, family dysfunction and the search for meaningful relationships – themes just as relevant today as they were to their original audiences. (See jewishindependent.ca/stories-that-explore-the-mind.)

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photo - The National Autism Research Centre of Israel — The National Autism Research Centre of Israel *(photo from Canadian Associates of Ben-Gurion University of the Negev)*

The Azrieli Foundation recently donated $15.6 million Cdn to the National Autism Research Centre of Israel, a collaboration between scientists from Ben-Gurion University of the Negev and clinicians from Soroka University Medical Centre (SUMC), both in the city of Be’er Sheva, Israel. The centre, originally established by the Ministry of Science and Technology, is dedicated to translational research that aims to revolutionize diagnosis techniques and interventions for autism and other neurodevelopmental conditions. In honour of the donation, the centre has been renamed the Azrieli National Centre for Autism and Neurodevelopment Research.

A dedicated facility inside SUMC will be constructed that will double the space for working with children with autism spectrum disorder and performing research. It will house genetics/bioinformatics, biomarker-detection and neuroimaging labs. Existing data collection will be expanded to many autism clinics throughout Israel, where multiple types of clinical and behavioural data, biological samples (e.g., DNA and blood samples) and neuroimaging data will be collected. This data collection will enable the rapid expansion of the National Autism Database, which will triple in size within five years. New faculty members, post-docs and graduate students, as well as scientific, clinical, technical and administrative support staff will be recruited to manage the data collection and sharing effort.

***

photo - Naomi Azrieli, chief executive officer, Azrieli Foundation Canada, and co-chair, Azrieli Foundation Israel, at the Nov. 7 announcement in Montreal, which took place concurrently with the announcement in Israel — Naomi Azrieli, chief executive officer, Azrieli Foundation Canada, and co-chair, Azrieli Foundation Israel, at the Nov. 7 announcement in Montreal, which took place concurrently with the announcement in Israel. *(photo by PBL Photography)*

The Weizmann Institute of Science and Weizmann Canada recently received a donation of $50 million US from the Azrieli Foundation, to enable catalytic brain research with the establishment of the Azrieli Institute for Brain and Neural Sciences. A longstanding supporter of the institute, this latest donation adds to past philanthropic investments of nearly $30 million US by the foundation towards Weizmann research facilities and fellowships.

Weizmann’s Azrieli Institute for Brain and Neural Sciences, which will be located at the Weizmann Institute campus in Rehovot, Israel, will promote the full spectrum of neuroscience research, from basic, curiosity-driven studies to translational work of high clinical relevance, with global impact. The donation will enable the construction of a new building that will serve as a hub for neuroscience activities, facilities and technologies.

The Azrieli Institute will focus on research in the development of neural networks; perception and action; mental and emotional health, positive neuroscience; learning, memory and cognition; the aging brain; neurodegeneration; injury and regeneration; theoretical and computational neuroscience; development of innovative neurotechnologies; and integrative brain disorders.

BGU studies health tweets

Dr. Odeya Cohen (photo by Dani Machlis/BGU) and Dr. Rami Puzis (photo courtesy)

Ben-Gurion University of the Negev (BGU) researchers discovered patterns of significantly decreased joy, increased sadness, fear and disgust among healthcare professionals (HCP) in the largest social media study to track emotional changes and discourse during the COVID-19 pandemic.

In the study, a multidisciplinary BGU team analyzed more than 53,000 HCP tweets from followers of several hundred Twitter accounts of healthcare organizations and common HCP points of interest. The most significant topics HCPs discussed during the pandemic were COVID-19 information, public health and social values, medical studies, as well as daily life and food. Approximately 44% of their discourse was about professional topics during the entire 2020 year.

The research indicates data-driven approaches for analyzing social media networks are helpful as a method for exploring professional health insights during both routine clinical situations and emergencies. The study will be published in the Journal of Medical Internet Research. A preprint is already available online. It was funded by the BGU Coronavirus Taskforce and by an Israeli Ministry of Science and Technology coronavirus research grant.

“Our findings, which track increasing sadness and decreasing joy, should be a warning to health organizations of the importance of better mental health support to help HCPs cope with the emotional consequences of the pandemic,” say Dr. Rami Puzis of BGU’s software and information systems engineering department (SISE) and Dr. Odeya Cohen of the department of nursing. “Most interestingly, HCP tweets expressed greater levels of fear just prior to pandemic waves in 2020. This indicates that many HCPs, beyond those working in epidemiology, observed, and were adequately qualified to anticipate pandemic development.”

Puzis goes on to say, “This suggests that decision-makers could benefit from investing additional resources into listening to the broader HCP community to track and anticipate bottom-up pathways for developing health crises.”

– Courtesy Canadian Associates of Ben-Gurion University of the Negev

Ancient foods still popular

Dates being harvested from Hannah, a tree germinated from ancient seeds in Israel. (screenshot from arava.org)

The Mediterranean Diet is not a recent lifestyle development, but rather a form of eating going back to ancient times.

Based on the foods consumed by people living near the Mediterranean Sea, this diet contains lots of olive oil, legumes, unrefined cereals, fruits and vegetables. It includes fish and dairy products, such as cheese and yogurts. It allows for wine drinking and a bit of meat.

From the specialized field of Israeli agro-archeology, we can get an idea of what people once grew and ate – and a number of these foods are mentioned in the Torah.

In some instances, the sages understood why certain foods were healthy, as seen in this quote from Tractate Ketubot of the Babylonian Talmud: “Dates are wholesome in the morning and in the evening. They are bad in the afternoon, but, at noon, there is nothing to match them. Besides, they do away with three things: evil thoughts, sickness of the bowels and hemorrhoids.”

In September 2020, the Arava Institute harvested 111 very special dates – the first fruit of Hannah, a tree sprouted from a 2,000-year-old seed and pollinated by another ancient Judean date tree. Dr. Elaine Solowey, director of the Centre for Sustainable Agriculture of the Arava Institute, and Dr. Sarah Sallon, director of the Louis L. Borick Natural Medicine Research Centre of Hadassah Hospital, harvested these ancient dates in the culmination of a decades-long experiment to raise the biblical-era Phoenix dactylifera (date palm) from the dead. The date seeds were originally discovered in the 1960s, when Yigal Yadin excavated Masada.

And, in January 2021, Israeli archeologists published the discovery of thousands of olive pits off the southern coast of Haifa. These pits were embedded in stone and clay neolithic structures in a now-submerged area, but one that was probably once part of the northern coast. They date back to about 4600 BCE.

Tel Aviv University archeologist Dafna Langot points out that these pits were not from olives used for oil because, in the production of olive oil, the pits get crushed and, in this find, the pits were mostly still intact. The site’s proximity to the Mediterranean Sea may indicate that the seawater served to de-bitter, pickle and salt the olives. (To read the article “Early production of table olives at a mid-7th millennium BP submerged site off the Carmel coast [Israel],” visit nature.com/articles/s41598-020-80772-6. BP stands for “before the present.”)

There is no biblical reference to olive eating itself. But, at the ceremony in which Moshe’s brother Aaron and Aaron’s sons become the priests over the ancient Hebrews, they ate matzah with oil olive (Exodus 29:2). Indeed, olive oil seems to have the edge over olives as seen in R. Yohanan’s warning: olives cause one to forget 70 years of study, olive oil restores 70 years of study (Babylonian Talmud, Horayot 13b). Yet, in Numbers Rabbah 8:10, proselytes are praised using a comparison to olives: “just as there are olives for eating, preserving and for oil … so from proselytes came Bible scholars, Mishnah scholars, men of commerce and men of wisdom, men of understanding.”

Around the ancient Hula Lake – referred to by researchers as Gesher Benot Yaakov or GBY – Israeli archeologists have discovered different types of nuts, dating back to the Lower Paleolithic period (1.5 million to 200,000 years ago). Two types of pistachio nuts (Pistacia atlantica and Pistacia vera) are said to have been gathered there. (See “Nuts, nut cracking, and pitted stones at Gesher Benot Ya’aqov, Israel,” at pnas.org/content/99/4/2455.)

Pistachios are one of only two nuts mentioned in the Bible. Pistachios may have grown in the Garden of Eden (Genesis 43:11). Legend has it that the Queen of Sheba declared pistachios were to be enjoyed only by royalty, even decreeing that it was illegal for commoners to grow pistachio trees. The nuts were considered an aphrodisiac.

In the Middle East, both Muslims and Jews prepare pistachio-filled baklava for holiday celebrations.

photo - In biblical times, barley was used as fodder for donkeys and horses so, if a person ate barley, it was a sign they were poor — In biblical times, barley was used as fodder for donkeys and horses so, if a person ate barley, it was a sign they were poor. *(photo by Alicja / Pixabay)*

On the Gezer Calendar, which dates back to King Solomon’s era, the springtime months of Iyar and Sivan are noted as the time for harvesting barley, the first grain to ripen in Israel. On the status scale, however, barley was held in low regard. It was used as fodder for donkeys and horses (I Kings 5:8). Thus, in biblical times, if you ate barley, it was a sign you were poor. At recent Israeli archeology digs, onsite workers collected barley seeds from the epipaleolithic period, some 20,000 to 10,000 years BP.

In addition, Israeli archeologists have identified 1,000-year-old eggplant seeds. They found the seeds in cisterns located in an ancient market complex that was discovered in Jerusalem’s Givati Parking Lot dig, more or less across from the Old City’s Dung Gate. The cisterns apparently had been left behind in either cesspits or garbage pits and the eggplant seeds had neither rotted nor disintegrated. Researchers surmise that the market stall owners used garbage pits to hold their unused stock or to discard damaged produce. Eggplant seeds found in cesspits were seeds consumed and naturally eliminated.

Eggplants are well-traveled. According to the late Gil Marks, in his cookbook Olive Trees and Honey: A Treasury of Vegetarian Recipes from Jewish Communities Around the World, eggplants originated in India some 4,000 years ago. By the fourth century CE, eggplants arrived in Persia. From, there they were “picked up” by Arabs, who probably brought them to Spain in the ninth century. Claudia Roden writes in her book The Book of Jewish Food: An Odyssey from Samarkand to New York that Jews came to be associated with eggplant when they fled the Almohades and Almoravides and when the Inquisition banished them from southern Italy.

Seeing that pomegranates are part of the Rosh Hashanah table, I’ll close with some information about the ancient fruit, one of the seven species mentioned in Deuteronomy 8:8. The Roman Pliny the Elder, who died in the 79 CE eruption of Mount Vesuvius, also had something to say about this juicy fall fruit – he wrote that the wild pomegranate seed, taken in drink, is curative of dropsy (edema).

Pomegranate seed oil contains high concentrations of Omega 5, which is believed to be one of the most powerful antioxidants in nature. Prof. Ruth Gabizon and Prof. Shlomo Magdassi from Hebrew University and Hadassah Hospital are hopeful that their pomegranate seed oil research will lead to a way of slowing down or lessening the effects of degenerative brain diseases.

A 2020 report by other researchers, which was published in The American Journal of Clinical Nutrition (doi.org/10.1093/ajcn/nqz241), contends that pomegranate juice helps maintain visual memory skills in middle-aged and older adults. The authors of the study state that it could have a potential impact on visual memory issues commonly associated with aging.

The old Mediterranean diet continues to provide new promise.

Deborah Rubin Fields is an Israel-based features writer. She is also the author of Take a Peek Inside: A Child’s Guide to Radiology Exams, published in English, Hebrew and Arabic.

Haas talks acting and BGU

Israeli actor Shira Haas was the featured guest at the Canadian Associates of Ben Gurion University of the Negev’s virtual gala July 7. (photo by Shula Klinger)

On July 7, the Canadian Associates of Ben Gurion University of the Negev held their second virtual fundraising gala. More than 1,200 participants logged on to the An “Unorthodox” National Virtual Gala event, which raised $850,000 for brain research at BGU’s Zlotowski Centre for Neuroscience.

The Zlotowski Centre is a group of researchers dedicated to finding cures and management tools for neurodegenerative diseases including Parkinson’s, Alzheimer’s, ALS and epilepsy.

photo - As part of the gala event, attendees received a special dinner package — As part of the gala event, attendees received a special dinner package. *(photo by Shula Klinger)*

Months in the making, the virtual gala was the work of a countrywide team of BGU staffers and numerous volunteers. Every participating household in Metro Vancouver received sweet and savoury kosher treats from Café 41. The accompanying gift box also brought olive oil from the Negev, a copy of Deborah Feldman’s memoir, Unorthodox: The Scandalous Rejection of My Hasidic Roots (Simon & Schuster, 2012), appetizer dishes and a commemorative cutting board.

Danny Chamovitz, BGU’s president, spoke about the work of BGU’s academics in general, in disciplines ranging from public health to brain research. Canadian Senator Linda Frum conducted the feature interview – with multiple-award-winning actor Shira Haas.

Describing herself as “very, very shy” as a young person, Haas said she had considered psychology or graphic design as professions, until a casting director approached her on Facebook. Sixteen years old at the time, she said, with respect to that first project, “I understood that this is what I want to do, it was like the door to Narnia.”

Haas does not take her success or popularity for granted. “It was always a dream to work internationally, in different languages, for different audiences, but I never imagined it,” she said. “It was always about the work. I am very, very lucky to be in this position.” She added, “My parents deserve to be talked about! They are the most supportive and amazing parents.”

Known for taking on demanding roles, Haas approaches acting in a scholarly fashion. She studied musculoskeletal diseases to play a terminally ill woman in the film Asia, and researched Russian, Yiddish and Charedi culture for the series Shtisel and Unorthodox. She said she finds beauty in hard work, explaining that Asia was “challenging in the most beautiful way. It was a lot of physical and emotional work, and very personal for me.”

When playing a part, Haas said she is motivated by two things. First, she must be passionate about the role because “that’s what brings everything alive.” About Shtisel, she said, “I fell in love with it immediately.”

Her second principle is to portray “subjects that matter to me.”

Haas’s idealism was evident in the way she spoke about Asia. “It’s not really about death,” she said. “It’s about relationships, about appreciating the time we have and what we do with it. The highest form of art is to bring light to the darkness.”

About Unorthodox, she said, “It didn’t occur to me that it is about the Orthodox world. It was just a story about people who want to be loved, their doubts, desires and failures.”

And Shtisel, she noted, had a huge impact on people all over the world. The show helped change people’s view of Orthodox communities, she said: “It’s universal.”

Of her forthcoming portrayal of Golda Meir in her early years, Haas described a woman with “a very interesting life. She was very passionate, with many dreams and desires.”

Since David Ben-Gurion and Golda Meir were friends, she laughed, “this event was meant to be!”

Haas spoke of her personal connection to BGU. Her sister studied at the university and a close friend is there now. Haas wanted to participate in the gala for several reasons, including, she said, “I am Jewish, I am an Israeli. I want to keep on doing events like this! I am even more proud to do it for Ben-Gurion.”

As for the brain research being conducted at BGU, which the gala funds will support, there has already been groundbreaking progress. Claude Broski’s group has identified a protein that can slow down the degeneration brought on by Parkinson’s. The social robots developed by Shelley Levy-Tzedek and her team will have an impact on stroke patient recovery – the robots offer motivation, feedback and performance-tracking during the rehabilitation phase. Epilepsy researchers are developing wearable hardware and software that could alert patients to an oncoming seizure, an hour before it happens. And Deborah Toiber’s Alzheimer’s team is exploring questions about brain aging, such as, Why does the disease affect so many of us, when only 5% of cases are genetic?

David Berson, executive director of CABGU, British Columbia and Alberta, said, “It has been very gratifying to see how the Metro Vancouver community has embraced BGU students and faculty in recent years. Many new supporters have stepped forward during the last year to engage with us. We are especially grateful to our community partners, who helped us promote this Unorthodox event.”

Among the many contributors to the gala were board members Jay Eidelman and Si Brown. Rachelle Delaney helped Berson with the goodie boxes at the crack of dawn on July 7, while volunteer drivers delivered the boxes. Adrian Cantwell and I were co-chairs for the Metro Vancouver team.

Shula Klinger is an author and journalist living in North Vancouver. She was Metro Vancouver co-chair of the CABGU gala with Adrian Cantwell.

Making aging healthier

Shira Haas is the featured guest at the July 7 event organized by Canadian Associates of Ben-Gurion University of the Negev. (photo from CABGU)

Israeli actress Shira Haas, star of the popular Netflix series Shtisel and Unorthodox, has been busy in recent months. Not only is she preparing to take on the role of a young Golda Meir in the upcoming series Lioness, executive produced by Barbra Streisand, but she is also the featured guest at the Canadian national virtual gala in support of Ben-Gurion University of the Negev (BGU) on July 7.

An “Unorthodox” National Virtual Gala for Brain Research, organized by Canadian Associates of Ben-Gurion University (CABGU), BGU’s Canadian fundraising arm, will raise money for the Canada Fund to Advance Brain Research.

“We are thrilled to share this exciting announcement with our community,” said Mitchell Oelbaum, national president of CABGU.

“According to the World Health Organization, there are approximately 50 million active cases of dementia worldwide, with an estimated 10 million new cases being added each year. Ten million people battle Parkinson’s each year globally. And, according to the World Stroke

Organization, 13 million people suffer from stroke annually. We wanted to do our part to help improve the chances of finding a cure for these debilitating diseases.”

The numbers are large, and there are no signs of a slowdown. That is why the fund was established by CABGU, with the goal of supporting groundbreaking and cutting-edge research for neurodegenerative diseases at the university’s Zlotowski Centre for Neuroscience.

“We are getting closer to determining the causes of age-related neurodegenerative diseases,” explained Dr. Debra Toiber of the department of life sciences in the faculty of natural sciences at BGU. “It’s an exciting time to be a scientist and uncovering the mechanisms of aging.”

Toiber is one of 67 researchers at the Zlotowski Centre. Her lab recently discovered that the SIRT6 protein is critical for the prevention of neurodegeneration, which can lead to Alzheimer’s and Parkinson’s diseases. Colleague Dr. Shelly Levy-Tzedek’s lab studies the impact of age and disease on the control of body movement and how best to employ robotics to facilitate a fast and efficient rehabilitation process. Meanwhile, Dr. Claude Brodski, also with the Zlotowski Centre for Neuroscience, is currently conducting a study, albeit in its early stages, that may offer a disease-modified drug target to address the impact of Parkinson’s. While these findings are encouraging, more research needs to be conducted.

“CABGU launched the Canada Fund to Advance Brain Research at BGU in April,” said CABGU chief executive officer Mark Mendelson. “Our team has been hard at work ever since, and there is a strong appetite for this subject matter here in Canada. The sad reality is that we all know someone, whether it is a relative, a friend or a neighbour, who is struggling with one of these devastating brain diseases.”

The national virtual gala is already more than 50% sold out. To learn how to become a sponsor or to purchase tickets, head to bengurion.ca.