science – Jewish Independent

Complexities of autism

Israeli neuroscientist Dr. Ilan Dinstein was in Vancouver last month to talk about autism research. (photo by Adele Lewin)

Neuroscientist Dr. Ilan Dinstein was in Vancouver last month to share research and expand knowledge on best practices internationally. An associate professor of psychology and cognitive and brain sciences at Ben-Gurion University of the Negev (BGU), Dinstein is the director of the new National Autism Research Centre (NAC) in Israel.

David Berson, executive director of the Canadian Associates of BGU for British Columbia and Alberta, told the Independent: “CABGU was delighted to be a part of hosting Dr Ilan Dinstein in Metro Vancouver. This visit was spearheaded by Dr. Grace Iarocci, Dr. Elina Birmingham and Dr. Sam Doesburg from SFU [Simon Fraser University] and Dr. Tim Oberlander from B.C. Children’s Hospital.

“Ilan Dinstein is a true reflection of the pioneering spirit that is unique to the Negev region of Israel, where, over the past five years, clinicians from Soroka University Medical Centre and researchers from Ben-Gurion University of the Negev have organically come together to collaborate for the betterment of all of the residents with ASD [autism spectrum disorder] in the region.”

Dinstein spoke with the Independent about the new centre and the purpose of his visit to Canada.

“We started the centre five years ago, to try to understand different causes of autism,” he said. “Autism is not one disorder. There are different sub-types of autism, with different possible roots and risk factors. Some of those factors are biological or genetic; others might be environmental. For example, a premature birth might be a risk factor in the child developing autism. Or the age of the parents – a child of older parents might have a higher risk of autism diagnosis than if the same parents were younger. We at the centre are trying to discover how the combination of genetic and environmental issues affects autism development.”

According to Dinstein, one of the reasons for the creation of the centre was the way science is funded in Israel. “The funding usually comes for one specific question,” he explained, “but autism is a complex, systematic disorder and it needs many facets of study, measurement and research; it needs collaboration and sharing of information. At the centre, we are able to combine different fields of study with the clinical applications, as we work together with the Soroka medical centre.”

The scientists of the NAC study autistic patients from different multidisciplinary angles: neuroscience and cellular biology, language pathology and motor tracking, even facial features.

“The truly unique thing is that we do all our studies inside the hospital,” Dinstein said. “Parents come in with their children, usually when the children are about 3 years old and the parents and the children’s teachers notice the kids’ uncommon behavioural patterns. The diagnosis of autism usually takes four visits. During those visits, we work in collaboration with the doctors, measuring various characteristics of the child’s development to arrive at the right diagnosis.

“We also started a database of all our patients, so we have a centralized well of knowledge about how various biological, cultural and social factors might contribute to autism development.”

Of course, not all of the parents agree to have their child added to the database, but Dinstein said that their recruitment rate is about 80%.

After the diagnosis, the scientists participate in determining a personalized treatment program, based on their research. “Such a program might include teaching the children useful behavioural habits, helping them with language acquisition or providing occupational therapy,” explained Dinstein. “Some autistic kids are very agitated and certain motions, like spinning, might calm them down. Sometimes, autistic children need to learn basic skills: how to dress themselves or brush their teeth.”

Pharmaceuticals can also help children cope with autism, but Dinstein said that only about 10% of patients use medications.

At the NAC, the scientists don’t treat patients, but rather study and make recommendations, develop new technologies and new methods of dealing with the disorder. Working together with clinical professionals, they hope to contribute to a higher rate of success in treatment.

One of the most important aspects of Dinstein’s and his colleagues’ work is an annual follow-up on the patients in the database. Families are required to come back once a year after the initial diagnosis, so the service providers can see their progress, determine what worked and what didn’t, and adjust their recommendations accordingly.

“We are still in the process of enlarging this project,” said Dinstein. “We want to open other locations in Israel, make our database to cover the entire state of Israel.”

The centre’s autism research, in particular its database of patients with autism, inspired interest locally, from scientists and clinicians to families and service providers. The invitation for Dinstein to visit Vancouver came from a range of people.

“Your researchers want to create a similar database to ours, Canada-wide,” said Dinstein about his presentation at the Children’s Hospital. “I met with scientists from UBC [University of British Columbia] and SFU, even some from Victoria. I also met medical professionals, parents, some service providers and stakeholders. I see these meetings as the beginning of a close relationship between autism research in Israel and in Canada. There are similarities there, but there are differences, too. Both countries have different ethnic maps, cultural traditions and genetic variations. We all want to know how such diversity affects autism.”

Olga Livshin is a Vancouver freelance writer. She can be reached at [email protected].

How can we be happy?

Left to right are Canadian Friends of the Hebrew University Vancouver president Stav Adler, CFHU Vancouver executive director Dina Wachtel and Hebrew U’s Prof. Yoram Yovell. (photo from CFHU Vancouver)

The happiest time in the average person’s life is when the last grown child leaves home and the dog dies. That was the tip of the iceberg in happiness advice from one of world’s foremost experts and researchers on the subject.

Prof. Yoram Yovell, a psychiatrist, brain researcher, psychoanalyst, author and media phenomenon in Israel, spoke to an overflow crowd at Beth Israel Synagogue July 25. An associate professor in the division of clinical neuroscience, Hadassah Ein Kerem Medical Center, at the Hebrew University of Jerusalem, Yovell is author of two bestsellers: Brainstorm and What is Love? He hosted the award-winning primetime TV show Sihat Nefesh (Heart-to-heart Talk) for 10 years. His visit was presented by Canadian Friends of the Hebrew University of Jerusalem and made possible by the Dr. Robert Rogow and Dr. Sally Rogow Memorial Endowment Fund in Support of Academic Lectures.

Yovell speculated that the audience was so large because of a sad fact about Vancouver.

“Now I understand why all of you are here,” he said. “I didn’t know this before I came here – you are considered to be the unhappiest city in Canada.”

He supposes this status might have to do with the combination of rainy days and the proportion of new Canadians, because “immigrants, for very important reasons, happen to be less happy than people who live in the same place where they were born,” he said.

But advancing happiness (or ameliorating unhappiness) requires us to define it, he said. He asked the audience to raise their hands if they were happy – most did – but then he demanded to know how they knew they were happy.

“That question sounds silly,” he said. “Because happiness is a subjective mental state. It’s something that I feel inside.… You probably did with yourself something that you would have done had I asked you, are you hungry or not hungry? Are you hot or cold? Are you tired or awake? In all the circumstances, people look inside and try to get a certain feeling and then that’s what they report. By doing so, we are treating happiness as if it’s something we feel. I’m not saying it’s bad that happiness is something we feel, but I think we have lots to gain by really questioning whether happiness is something that we feel or something that we do.”

Aristotle, who wrote a lot about happiness, differentiated hedonia, pleasure, from eudaimonia, a much more complex concept that has more to do with achieving one’s potential in every aspect of our lives.

Instead of asking, “Are you happy?” Aristotle would ask, “Are you the best doctor you can be, the best husband, the best parent?”

Yovell said, “And, if the answer is yes, or almost yes, to most of those questions, then, for Aristotle, I’m eudaimonia and he doesn’t care how I feel.”

Tal Ben Shahar, an Israeli who wrote the book Happier about 2,400 years after Aristotle’s ponderings on happiness, developed a simple equation: happiness equals pleasure plus meaning. This dictum is, Yovell said, the only thing that every school of philosophy and every religion agrees on. Pleasure does not equal happiness. Meaning is the additional ingredient that turns fleeting pleasure into lasting happiness.

“The contribution of pleasure to happiness is there, but it’s small,” said Yovell. “And what’s even more important is it does not last, whereas the contribution of meaning to our happiness is huge and it’s stable. That makes an enormous difference to how we should conduct our lives if we want to be happier.”

One example he discussed was a study showing that most parents say, in retrospect, that child-rearing is the thing that made them happiest. But ask them when they’re changing diapers, doing laundry or settling squabbles, and they’ll tell you their happiness level is in the basement.

“It doesn’t really matter what you felt in the meantime,” he said. “What matters is what is kept in your memories. We live in our memories.”

Having children, for most people, is the most meaningful thing they’ve ever done, said Yovell.

“Pleasure is good. Have a good dinner, have a vacation abroad, upgrade your car model – all these things are going to make you happier. But not to a great degree and not for very long,” he said. “The things that are going to make us happy long-term are the things that give our lives meaning.”

Still, the road to happiness can be arduous.

“If you take a regular couple and ask, ‘When are these two people going to be at the top of their marital happiness?’ the answer is a short time after they get married and, with every child they have, their level of happiness decreases. And when their first child hits adolescence …” at this point his words were drowned out by the laughter and applause of the audience. “You know what I’m talking about, right?” he said.

“But there is light at the end of the tunnel,” he continued. “For those of us who manage to bypass this ‘Death Valley,’ there is going to come a time in our marital life where our happiness level [improves]. The vast majority of you are going to get happier … the older you become, the happier you’re going to be.”

A study of 340,000 American men and women looked at the correlation between their well-being and their age.

“At 18, they’re pretty happy – before they’ve realized what’s going to happen,” said Yovell. “Soon, they go off to college and there goes their happiness and they keep going down and down and down and it gets worse and worse and then they hit rock bottom here, in the 40s and 50s,” he said, pointing at a slide on the projection screen. “But, it gets better as they get older, sicker, less attractive, closer to death – and happier.”

Yovell’s academic work has often focused on reducing extreme unhappiness so that, for example, suicidal people are improved enough to be brought back from that brink.

He cited Sigmund Freud, a founding board member of Hebrew University, noting that “many things that Freud hypothesized were proven wrong, but many were proven right.” One example, he said, was Freud’s observation in his first book that “Much will be gained if we succeed in transforming hysterical misery into common unhappiness.”

The science of happiness has advanced dramatically in just the past two decades, Yovell said. We now know that the parts of the brain that register physical pain overlap with those that register emotional pain.

“This is something that 20 years ago we knew absolutely nothing about and now we do. In the last two decades, we’ve gradually learned that it is true that mental suffering is encoded in our brains using the same neural pathways, the same neurotransmitters that also mediate the extremes of physical pain.”

If you ask a friend about the most painful thing they’ve experienced in their life, they are unlikely to tell you about a ski accident or an operation, he said.

“They’re going to tell you about the loss of a first-degree relative. They’re going to tell you of how they felt when a father, a mother, a sibling, a spouse or, God forbid, a child has died and has left them bereaved,” said Yovell. “That, for most of us, is going to be the most painful thing in our life.”

Similarly new research indicates that emotional pain is something we can quantify, that it is more than subjective. With this knowledge, Yovell said, the follow-up question is: “Can we make it better and, if so, how?”

First, it is important to understand what we can control and what we cannot.

In 2014, a study looked at the relationship between happiness and genetics and concluded, the professor said, “that our genetics do influence our happiness but they are responsible for about 32% of our happiness, which means that 68% of our happiness – more than two-thirds of how happy or unhappy we’re going to be – has something to do with us. Part of it is the circumstance into which you were born, but the rest is how we conduct our lives – both our real lives out in the world and our inner world, our mental lives. This is what we have to work with and that ain’t bad.”

Yovell described a study of university students, in which a control group was given a placebo and another group regular-strength Tylenol and participants were then asked to journal about how they felt with their ongoing lives on campus.

“Those who got Tylenol instead of placebo actually experienced those mental pains to a lesser degree,” he said. “That’s nice, but that ain’t going to do the job when things get more difficult when someone, God forbid, loses a spouse or when someone sinks into a big depression. Tylenol will not be the answer. But what about opioids? What about narcotics? What about those drugs that mitigate the effects of endorphins. Do they make mental suffering better? And, if so, at what price?”

Opioids were used in the treatment of depression for at least 100 years, he said, between the mid-19th and mid-20th centuries.

“Drugs like morphine and codeine were the first drugs of choice in the treatment of mental depression and they actually worked,” he said. But the problems were threefold. These drugs induce tolerance, meaning a patient has to increase the dose in order to achieve the same effect. Narcotics or opioids also cause addiction and that’s a huge problem. And they are easy to overdose on.

Recently, scientists have begun investigating the use of the opioid buprenorphine.

“It’s less addictive and it’s much less dangerous in overdose because, if you give it in high doses, it actually blocks its own effect, so it’s very, very hard to overdose on,” Yovell said. “Even though it’s 40 times more potent than morphine, it’s actually a lot less dangerous to overdose and also less addictive.… We took people in Israel who are not only incredibly depressed but also suicidal. In addition to existing treatments for their depression and suicidality, the experiment added buprenorphine to their regimen.… Those who received the active drug, unbeknownst to them and to us as well, continued to improve. So there is hope, which is very nice.”

A drug-free way to marginally increase one’s happiness, he said, is simple goodness, generosity and philanthropy. Making others happy makes us happy, he said.

“People who contribute their time and money, who volunteer, will not only be happier, they will live longer,” he said. He then directed audience members to donation forms on their tables and asked them to consider contributing to scholarships for graduate students who are working with him.

“I leave it up to you,” he said, “whether you want to save your lives.”

Parrot invaders

(photos from Ashernet)

A few years ago, the sight of a parrot in the Israeli sky was a rare event but invasive species have arrived, causing agricultural and other damage and threatening native biodiversity. Brought to the Middle East and Europe as pets, escaped or released parrots have established numerous wild populations across the area. ParrotNet – a European and Middle East network of scientists, practitioners and policymakers dedicated to research on invasive parrots, their impacts and the challenges they present – has concluded that measures to prevent parrots from invading new areas are paramount for limiting future harm. According to lead researcher Dr. Assaf Shwartz of the Technion in Haifa, “Today in Israel there are more than 200 populations of parrot species originating in South America and India…. These populations are growing every year and, today, there are more than 10,000 ring-necked parakeets and monk parakeets in Israel.”

שינויים ניכרים באזורים הארטקטיים

(Mario Hoppmann/NASA)

חוקרים בכירים ארה”ב: הקרח באזורים הארקטיים של קנדה החל להפשיר שבעים שנה לפני התחזיות

משלחת מאוניברסיטת אלסקה (בפיירבנקס) מצאה שינויים ניכרים בתוואי הקרקע הקפואה באזורים הארטקטיים של קנדה, במהלך שלוש עשרה שנים: בין אלפים ושלוש לאלפיים ושש עשרה. לפי הממצאים בנוסף לנסיגת שכבת הקרח נוצרו גם גבעות נמוכות, שחסמו את הרוח ואפשרו לצמחייה להכות שורש

שכבת האדמה הקפואה באזורים הארקטיים בקנדה החלה להפשיר שבעים שנה שנה לפני הזמן הצפוי. על כך מצביעים הממצאים של משלחת חוקרים בכירה שהגיע לאזור. לדבריהם התופעה מעידה על כך שכדור הארץ מתחמם בקצב הרבה יותר מהיר מכפי שצפו בתחזיות השונות. חברי המשלחת מאוניברסיטת אלסקה שבארצות הברית, אמרו כי הופתעו מאוד מהמהירות שבה גרמו עונות הקיץ החמות במיוחד לערעור השכבות העליונות של גושי הקרח התת־קרקעיים.

זה היה מדהים אמר לסוכנות החדשות הבינלאומית רויטרס, ולדימיר רומנובסקי, גיאו־פיזיקאי חבר במשלחת של האוניברסיטה. זה סימן לכך שהאקלים כיום חם הרבה יותר מאשר היה אי פעם – במהלך חמשת אלפים השנים האחרונות. החוקרים פרסמו את ממצאיהם המעניינים והיוצאי דופן בכתב העת המדעי גיאופיזיקל רייסרץ’ לטרס.

לפני מספר שבועות פורסמו הממצאים האלה ברבים- לקראת פסגת משבר האקלים שהתקיימה בבון שבגרמניה. האירוע הבינלאומי אורגן על ידי האו”ם וגורמים נוספים. זאת במטרה להגביר את המאמצים המשותפים למצוא פתרונות בנושא הכל כך מסובך. כידוע כל מדינות המערב תומכות ברעיון כי כדור הארץ מתחמם לפי ממצאים של המדענים השונים. ורק נשיא ארה”ב הנוכחי, דונלד טראמפ, מתכחש לממצאים אלה.

המאמר התבסס על ניתוח נתונים שהחוקרים אספו בביקורם האחרון באזור לפני כשלוש שנים. ובמקביל הוא מתבסס גם על סקירות אקלימיות מאז שנת אלפיים ושלוש ועוד היום. הצוות השתמש במטוס ששודרג במיוחד כדי לבקר בנקודות מרוחקות ביותר, בהן תחנת מכ”ם מתקופת המלחמה הקרה, שנמצאת במרחק של יותר משלוש מאות ק”מ מכל יישוב אנושי. כצפוי החוקרים לקחו על עצמם סיכונים גבוהים בביקור באזורים מרוחקים אלה. לדברי החוקרים ממש בנחיתה לקרקע נגלה לעיניהם נוף שונה לחלוטין על פני הקרקע הארקטית, שאותה ראו בביקורים קודמים לפני כעשור שנים.

הנוף הפך לים גלי של גבעות, שקעים צרים ובריכות. הצמחייה שבעבר היתה מעטה החלה לצמוח בכמות גדולה בחסות המקלט שסיפק הנוף מהרוחות הבלתי פוסקות. החוקרים הרגישו מצד אחד סיפוק מקצועי על כל מה מצאו, ומצד שני הרגישו תחושה שהאסון ממשמש ובא. הם ציינו כי המראה הזכיר להם אדמה חרוכה אחרי הפצצה.

זו תופעה המזכירה לי מכרה הפחם, אמרה אחת החוקרות הבכירות במשלחת. סביר למדי שתופעה זו משפיעה על אזורים נרחבים יותר ממה שאנו מעריכים. ואת זאת החוקרים יבדקו בהמשך. החוקרים חוששים ליציבות שכבת האדמה הקפואה בשל הסכנה שהפשרה מהירה תשחרר כמות נרחבת של גזים, שיביאו להאצה משמעותית של ההתחממות הגלובלית

לפי הערכות של האו”ם גם אם המחויבויות הקיימות בהסכם פריז משנת אלפיים וחמש עשרה, להפחתת פליטות גזי החממה, ייושמו במלואן העולם עדיין רחוק מאוד ממניעת הסכנה – שתהליכים דומים של היזון חוזר יביאו להאצת ההתחממות של כדור הארץ.

נוכח אזהרות המדענים כי טמפרטורות גבוהות יותר יגרמו להרס רב בחצי הכדור הדרומי, ויהוו איום על יכולת הקיום של העולם המתועש בחצי הכדור הצפוני, ארגוני סביבה נתלים במאמר שפרסמו החוקרים כהמחשת הצורך בהפחתת פליטות גזי החממה. הפשרת האדמה הקפואה היא אחת מהנקודות המצביעות על משבר האקלים, אמרה ג’ניפר מורגן מארגון גרינפיס אינטרנשיונל.

Happiness thoughts

Summertime and the living is easy! Of all the seasons, probably summer is most closely associated with happiness. Vacation, camping, family time, celebrations, picnics: these are activities that we associate with happiness.

In Western culture, individual happiness is often considered the primary goal of life. What parent hasn’t begun a sentence with, “As long as you’re happy…”? In many other societies, happiness is subordinated to family needs, communal obligations or other less individualistic pursuits. But the pursuit of happiness has a long history in Western culture, codified most notably in the United States Declaration of Independence as an “unalienable right.”

Most of us probably enjoy our happiness without overthinking it. But an Israeli guru of happiness will be in Vancouver later this month and he has thought a great deal about the subject.

Prof. Yoram Yovell is a brain researcher, psychiatrist and psychoanalyst with a PhD in neurobiology. He is the author of bestselling books and is a regular face on Israeli TV.

The United Nations ranks countries on a scale of happiness, topped by the Scandinavian countries, Switzerland, the Netherlands, Canada, New Zealand, Australia – and then Israel.

For people who have not been to Israel or who lack an understanding of its culture, it may be a surprise to find that a country whose history has been so wrapped up in violence and conflict would produce a population that is collectively as happy as almost any society in the developed world. There is, however, an explanation.

Stability, basic freedoms and an economy that allows for individual financial comfort or success are among the baseline requirements for societal happiness, notes Yovell. Things like clean water, a social safety net and an effective, accessible healthcare system are also on the list. In many cases, it is also critical to have a sense of cohesion and shared purpose.

While Israelis may no longer be as united as they were in the days of the early chalutzim, the requirement of military or national service plays a factor in building social cohesion and making individuals feel part of a larger whole. For many, the ability to live in the world’s only Jewish state is another factor that leads to shared purpose and, indirectly, to happiness. (It is worth noting that, although Israeli Arabs report being less happy than Jewish Israelis, their happiness levels are higher than Arabs in neighbouring countries.)

Economic challenges in Israel – inflation, high cost of living and such – do not ultimately have a huge influence on happiness levels, Yovell maintains. Once the most basic needs are met, incremental differences in income or GDP have little impact.

We could all take some time this summer to reflect on the things that make us happy. In so many cases, the things that make us happy are precisely the things that make our society better – volunteerism, engagement and participation in our community, getting outside (especially if it’s sunny!), spending time with family and friends. These are things we could all do well to be more conscious of, be grateful for and try to consciously encourage in our lives.

The making of ancient beer

Nanopores taken from ancient pottery have allowed researchers to make beer following a 5,000-year-old recipe. (photo by Yaniv Berman IAA via Ashernet)

Research led by scholars at Hebrew University, the Israel Antiquities Authority, Tel Aviv University and Bar-Ilan University has revealed a way to isolate yeast from ancient pottery, from which beer was then produced. HU’s Dr. Ronen Hazan and IAA’s Dr. Yitzhak Paz, who are among the leaders of the research, noted that “we now know what Philistine and Egyptian beers tasted like.” The team examined the colonies of yeast that formed and settled in the pottery’s nanopores. Ultimately, they were able to use resurrected yeast to create a beer that’s approximately 5,000 years old.

“By the way, the beer isn’t bad,” said Hazan. “Aside from the gimmick of drinking beer from the time of King Pharaoh, this research is extremely important to the field of experimental archeology – a field that seeks to reconstruct the past. Our research offers new tools to examine ancient methods and enables us to taste the flavours of the past.”

Added Paz, “This is the first time we succeeded in producing ancient alcohol from ancient yeast. In other words, from the original substances from which alcohol was produced. This has never been done before.”

Sniffing helps us think

Subjects given problems to solve as they inhaled did better on tests. (image from wis-wander.weizmann.ac.il)

A shot of espresso, a piece of chocolate or a headstand – all of these have been recommended before taking a big test. The best advice, however, could be to take a deep breath. According to research conducted in the lab of Prof. Noam Sobel of the Weizmann Institute of Science’s neurobiology department, people who inhaled when presented with a visuospatial task were better at completing it than those who exhaled in the same situation. The results of the study, which were published in Nature Human Behavior, suggest that the olfactory system may have shaped the evolution of brain function far beyond the basic function of smelling.

Dr. Ofer Perl, who led the research as a graduate student in Sobel’s lab, explained that smell is the most ancient sense. “Even plants and bacteria can ‘smell’ molecules in their environment and react,” said Perl. “But all terrestrial mammals smell by taking air in through their nasal passages and passing signals through nerves into the brain.”

Some theories suggest that this ancient sense set the pattern for the development of other parts of the brain. That is, each additional sense evolved using the template that had previously been set out by the earlier ones. From there, the idea arose that inhalation, in and of itself, might prepare the brain for taking in new information – in essence, synchronizing the two processes.

Indeed, studies from the 1940s on have found that the areas of the brain that are involved in processing smell – and thus in inhalation – are connected with those that create new memories. But the new study started with the hypothesis that parts of the brain involved in higher cognitive functioning may also have evolved along the same basic template, even if these have no ties whatsoever to the sense of smell.

“In other mammals, the sense of smell, inhalation and information processing go together,” said Sobel. “Our hypothesis stated that it is not just the olfactory system, but the entire brain that gets ready for processing new information upon inhalation. We think of this as the ‘sniffing brain.’”

To test their hypothesis, the researchers designed an experiment in which they could measure the airflow through the nostrils of subjects and, at the same time, present them with test problems to solve. These included math problems, spatial visualization problems (in which they had to decide if a drawing of a three-dimensional figure could exist in reality) and verbal tests (in which they had to decide whether the words presented on the screen were real). The subjects were asked to click on a button twice – once when they had answered a question and once when they were ready for the next question. The researchers noted that, as the subjects went through the problems, they took in air just before pressing the button for the question.

The experiment was designed so the researchers could ensure the subjects were not aware that their inhalations were being monitored, and they ruled out a scenario in which the button pushing itself was reason for inhaling, rather than preparation for the task.

Next, the researchers changed the format around, giving subjects only the spatial problems to solve, but half were presented as the test-takers inhaled, half as they exhaled. Inhalation turned out to be significantly tied to successful completion of the test problems. During the experiment, the researchers measured the subjects’ electric brain activity with EEG and here, too, they found differences between inhaling and exhaling, especially in connectivity between different parts of the brain. This was true during rest periods as well as in problem-solving, with greater connectivity linked to inhaling. Moreover, the larger the gap between the two levels of connectivity, the more inhaling appeared to help the subjects solve problems.

“One might think that the brain associates inhaling with oxygenation and thus prepares itself to better focus on test questions, but the time frame does not fit,” said Sobel. “It happens within 200 milliseconds – long before oxygen gets from the lungs to the brain. Our results show that it is not only the olfactory system that is sensitive to inhalation and exhalation – it is the entire brain. We think that we could generalize, and say that the brain works better with inhalation.”

The findings could help explain, among other things, why the world seems fuzzy when our noses are stuffed. Sobel points out that the very word “inspiration” means both to breathe in and to move the intellect or emotions. And those who practise meditation know that the breath is key to controlling emotions and thoughts. This, though, is important empirical support for these intuitions, and it shows that our sense of smell, in some way, most likely provided the prototype for the evolution of the rest of our brain.

The scientists think their findings may, among other things, lead to research into methods to help children and adults with attention and learning disorders improve their skills through controlled nasal breathing.

Sobel’s research is supported by the Azrieli National Institute for Human Brain Imaging and Research; the Norman and Helen Asher Centre for Human Brain Imaging; the Nadia Jaglom Laboratory for the Research in the Neurobiology of Olfaction; the Fondation Adelis; the Rob and Cheryl McEwen Fund for Brain Research; and the European Research Council. Sobel is the incumbent of the Sara and Michael Sela Professorial Chair of Neurobiology.

For the latest Weizmann Institute news, visit wis-wander.weizmann.ac.il.

Synchronizing rhythms

Dr. Shimon Amir researches circadian rhythms and clock genes. (photo from Shimon Amir)

When our circadian rhythm is disrupted, it can cause a brain disorder that manifests in a series of detrimental conditions too numerous to list, but that includes insomnia, depression and Parkinson’s disease.

“Circadian rhythms are daily observations in behavioural, physiological and metabolic processes,” explained Dr. Shimon Amir, professor of psychology, Concordia University in Montreal, and director of the university’s Centre for Studies in Behavioural Neurobiology. “In fact, everything you can measure in an organism follows a daily rhythm – a 24-hour cycle generated by internal clocks present in each and every cell in our bodies. And they are synchronized with the environmental light cycle. So, there is tuning between the internal rhythms and the solar cycle. Those are the rhythms.

“Most people might think that rhythms are driven by the light-dark cycle, but that’s not the case. They are generated by a clock that is present in every cell. The clocks are made of a set of genes called ‘clock genes’ and they oscillate – form feedback logs that last each cycle, with each cycle lasting about 24 hours.”

Amir was born and raised in Israel and moved to Montreal for his PhD. He went back to Israel to work at the Weizmann Institute of Science, but later returned to Montreal to teach and do research on circadian rhythms and now, too, clock genes.

According to Amir, circadian rhythms allow organisms like flies, rats, monkeys, humans and even plants to anticipate and respond to the demands of their environment.

“Rhythms can be disrupted by various means,” he said. “Ones that are most common are traveling across time zones, working shift work and eating at the wrong times. But, the main reason for the disruption is movement across time zones. Your clock is synchronized to your location. So, if you move from, say, Vancouver to Montreal, the clock has to be advanced, as you’ll wake up in Montreal three hours earlier, right? That takes time and the mismatch between environment and internal cycles causes various metabolic, behavioural, cognitive and other problems.”

While there are clocks in every cell of the body, all these clocks report to the master clock in the brain. That clock receives input from the eyes – light information that resets the master clock daily.

When we use lights at night, the master clock gets disrupted. “The clock is very sensitive to light at night,” said Amir. “Say you’re asleep and you want to go to the bathroom in the middle of the night. You turn on the light and that causes a disruption of the clock. Another way to disrupt the clock is the time that you eat. Eating should occur during the day.

“The reason light is so disruptive at night is that one arm of the clock is a hormone called melatonin. Melatonin is exceedingly sensitive to light. It is secreted during the night and is suppressed during the day. But, if you turn on the light at night – even very brief exposure to light at night – it suppresses the melatonin rhythm.”

Amir suggested using a sleep mask to keep light away, as well as learning to use the washroom at night without turning on a light. “You can adapt to the dark very quickly and be able to see,” he said.

While Amir’s initial research interest was in circadian rhythm, over the last 10 years, he has expanded his focus to other clocks in the brain – those that control different types of behaviours and pathological conditions, such as depression, anxiety, drug addiction and diseases like Parkinson’s.

Through experiments with mice and rats, Amir has been working to configure which brain clock controls, or affects, how the rodents handle stimulation and what happens if these clocks are turned off or disrupted.

“So, the clocks are made of several particular genes called clock genes,” said Amir. “We have various molecular, genetic and viral tools to manipulate those genes directly … in different regions of the brain…. We’re seeing what happens when an animal that has a brain region that doesn’t have a clock or particular clock gene that stops the clock … how the animal behaves and what are some of the pathological consequences of this condition.”

Amir and team use various animal models of disease, looking into what happens when you take out the clock and if it correlates with enhanced depression and anxiety.

“The circadian rhythm is really a very fundamental system that you can say controls everything,” said Amir. “When the system is disrupted, it has important implications for varied disorders.”

photo - Dr. Shimon Amir — Dr. Shimon Amir *(photo from Shimon Amir)*

The main goal is to understand the evolutionary function of the clocks and what they do to enable adaptation of organisms to their surroundings. But, also, the hope is that, by having better understanding, it will help in identifying new avenues of therapies.

With jet lag being such a hot topic in regards to circadian rhythm, Amir suggested a few ways to keep it at bay. “There are some ways to shorten jet lag, but there’s no way to avoid it,” he said.

“When you go east, you have to be exposed to light in the morning, in order to readjust to the new time zone. When you are exposed to light early in the morning, it induces in the clock a ‘face advance,’ it advances the clock. But, if you go west, you have to be exposed to light at night, early night. The transition between the evening and night, that’s where you have to be exposed to light, and that’s where it is ‘face delay.’ It will delay the face of the clock, because you have to wake up later when you go west.

“You need to be intentionally exposed to light in the evening or have light exposure a bit longer before you go west … or wake up very early, be exposed to light early in the morning, if you go east.

“Going through jet lag is very unhealthy,” he said. “If you do it very often, it will affect you in various ways, negatively, of course. Except, you can’t avoid it … as you go see family and grandchildren, and others, in Israel.”

Rebeca Kuropatwa is a Winnipeg freelance writer.

Meet new or favourite writers

The Cherie Smith JCC Jewish Book Festival starts this Saturday night (Feb. 9) with Joshua Cohen, author of Moving Kings and ATTENTION: Dispatches from a Land of Distraction. It continues for five literary-filled days at the Jewish Community Centre of Greater Vancouver, and here’s a sampling of books you might want to add to your reading list, and authors you might like to meet.

Set in 1920, in the fictional shtetl of Golikhovke during the Russian civil war, Judgment, by David Bergelson (1884-1952), is a melancholic novel about humanity in a time of uncertainty, where different political factions are warring, each under their own ultimately meaningless banner; neighbours cannot trust one another, let alone strangers; and justice is meted out randomly by a cruel, indifferent force.

Stationed in an also fictitious abandoned monastery called Kamino-Balke, near Golikhovke, the sickly Bolshevik Filipov is in control of the area along the Ukraine-Poland border. There are smugglers who travel across the border for commercial reasons and Socialist Revolutionaries who travel across it in preparation for an uprising against the Bolsheviks. Jews and non-Jews live together in relative tolerance but political loyalties, ethnic ties and differing ideas of morality ensure a constant tension. All live in fear of being captured by one of Filipov’s agents, as guilt of a crime does not need to be proven for a person to be beaten, imprisoned and/or shot.

What makes this novel beautiful is Bergelson’s prose. Imaginative metaphors: “Large, invisible hands merrily picked up whole heaps of snow and just as merrily released them.” Animated objects: “… the coat lay there bent over, dejected, as if it had made a long, pointless, idiotic journey” and “The cannons’ muzzles – black, fat and eyeless – stared longingly in the direction of the forests around Moshne….” Humour: “Stone fences suited the inhabitants of Yanovo, for all of them were as stubborn as their stone fences: stone upon stone.” And empathy, in this case, for the undercover agent Yokhelzon, whose “eyes (which inspected everything, people said) had already taken in the horror of death – they winked joyfully, so that the horror would not show afterward.”

As should be obvious, Harriet Murav and Sasha Senderovich have done a masterful job of translating Judgment from Yiddish to English. They also provide a fascinating introduction to the novel, its historical context, the author and his other works (Bergelson was executed in 1952, on Stalin’s orders), the book’s title, form, themes and use of language.

Senderovich will be at the book festival on Feb. 10, 3:30 p.m.

***

Michèle Smolkin’s novel Silence, je tombe is a witty, philosophical novel that explores how people can become isolated from one another, including themselves. Told from the perspectives of a few protagonists, readers will likely relate to many of the feelings expressed.

The novel starts with a pregnant Tania, as she, her husband Paul and their toddler Margot are making the drive to their new home in “Manhattan, Kansas, The Little Apple,” from Vancouver. Tania’s disenchantment is obvious and she expresses her anger towards her husband – who, as a professor of philosophy, couldn’t find a job elsewhere – with vicious (and very funny) sarcasm, mostly in her thoughts, but aloud, as well. She had imagined a different life for herself – living in New York, the Big Apple, for one thing; and certainly not in the Bible Belt. As a Francophone Jew, she anticipates that fitting in might be a problem.

As the book progresses, we get to know Tania, Paul and a disturbed man named Kevin, plus a couple of other minor but important characters. Through them, we contemplate love, what attracts people to one another and what forces them apart, what happiness is, what actions might be unforgivable, how our childhoods influence our adulthoods, and, of course, the inadequacy of words for certain situations, and understanding why, sometimes, silence is the only possible response.

Smolkin’s talk – the book festival’s first-ever French-language event – will take place Feb. 10, 5 p.m. (Note: Festival program shows incorrect time.)

***

A River Could Be a Tree is, thankfully, not the memoir of a person who goes from believing fanatically in one religion to being swept away as unquestioningly into another, though it might seem like it would be, given some aspects of the press material. “How does a woman who grew up in rural Indiana in a fundamentalist Christian cult end up a practising Jew in New York?” asks part of the blurb on the book flap. Well, for starters, Angela Himsel seems to always have been an inquisitive person, and never an avid follower of Herbert Armstrong’s Worldwide Church of God. She was an obedient child, but is still struggling with understanding how her parents believed so much in the church doctrine that they didn’t give her sister the care that might have prevented her death at a young age.

A River Could Be a Tree is a measured, often humourous, always intelligent memoir. Himsel starts with a prologue that gives readers a very large hint as to what led her to ultimately convert to Judaism: she and her boyfriend Selig were, “just once … careless about birth control.”

But the journey to that point is long and more complicated, and Himsel takes readers through it with the benefit of hindsight, hard-won insights and a writing style that is serious, honest but unsentimental, and filled with initially unexpected levity. As but one example, a mere three paragraphs into Chapter 1, in which Himsel talks about her parents’ religious heritage, Roman Catholicism and Lutheranism, she writes about Martin Luther, that, at age 41, he “married a nun, a woman he had helped smuggle out of a convent in a herring barrel. While irrelevant to Luther’s religious beliefs, a nun in a herring barrel is always worth mentioning.”

And A River Could Be a Tree is well worth reading. Himsel will speak at the book festival on Feb. 11, 7:30 p.m.

***

There is so much information in Why You Eat What You Eat: The Science Behind Our Relationship With Food by Rachel Herz. And a refreshing aspect of the book is that it’s not written from a dogmatic, all-knowing viewpoint. Herz acknowledges that sometimes studies come to different conclusions, sometimes scientific progress means that what was once thought true is disproven, and that different people will experience food, exercise and other things differently. Readers looking for certainty might be disappointed, but those wanting to learn will learn a lot. Who doesn’t want to know, for example, why tomato juice is one of the most popular drink orders on planes? Does sugar really help the medicine go down, so to speak, i.e. reduce the effects of pain? And why can buying ethically branded or organic products make us less charitable?

But Why You Eat What You Eat is more than an amalgamation of trivia. Herz has compiled a very readable and relatively comprehensive resource that will, as the title promises, help explain why we eat what we eat; how all of our senses – taste, smell, sight, touch and hearing – affect how we experience food. And knowing these things just might make us feel better about ourselves, and make choices that would serve us better.

Herz will be at the book festival on Feb. 13, 6 p.m.

Seeing with the brain

Prof. Amir Amedi of the Hebrew University answers questions from attendees at a Jan. 16 presentation. (photo by Pat Johnson)

A white cane has been used for generations to help guide the mobility of people who are blind. Researchers at the Hebrew University of Jerusalem created the EyeCane, which added technology that indicates to the user the distance to obstructions. From there, other technological advances were added to identify the types of items in the area – a couch, chairs, table, lamp – and convey the information to the user’s ear. Still not satisfied, the scientists combined the invention with artificial intelligence and complex auditory accompaniments so that the user could identify the size, shape, colour, brightness and other attributes of the space around them to get a full “picture” of their surroundings.

Presented by the Vancouver chapter of the Canadian Friends of the Hebrew University, Prof. Amir Amedi spoke at Schara Tzedeck Synagogue Jan. 16. Amedi is a professor in Hebrew University’s department of medical neurobiology and an adjoint research professor at the Sorbonne in Paris. He is currently a visiting professor at McGill University in Montreal.

The interdisciplinary marriage of computer science, neurology, philosophy, rehabilitation, physics and other fields is leading to unprecedented advances in aids for people with disabilities. Some of the foremost innovation is taking place at Hebrew University, where Amedi works with a large team across many faculties.

The EyeCane is just one example of the sorts of tools being developed in Amedi’s lab, items that are known as sensory-substitution devices (SSDs). The most common SSD is the written word, Amedi explained. For millennia, humans communicated only verbally. Written language is a device that substitutes two senses – speaking and hearing – into a different form: writing and reading.

Amedi discussed the development of agriculture, then cities, then written language, then printing, each of which took tens of thousands of years to evolve, allowing the human brain plenty of time to accommodate the changes. Today, though, new technologies come flying at us daily and the question this raises, according to Amedi, is how our brains are able to adapt so readily to such sudden changes – an issue Amedi refers to as a “real estate problem” in the brain.

“How can the brain, in the slow evolutionary process, adapt to more and more information, more and more technologies?” he asked.

One theory posits that parts of the brain get recycled to deal with cognitive tasks it has not previously confronted.

A parallel invention of Amedi’s lab is an auditory process that allows blind people to “see” with their brain. Sight is really a function of the brain, not the eyes, he said. The eyes are the conduit, but the brain does the cognitive work of seeing. Bypassing the non-functional eyes and going through the ears directly to the part of the brain where sight is computed, Amedi and his team have been able to create a complex musical language that allows blind people to absorb immense amounts of information about the environment around them.

In a demonstration, Amedi walked the audience through the first lesson users of the technology are taught. Simple sounds – similar to Morse code – represent lines. A musical scale going up or down represents stairs. A smile is depicted by a falling then rising tone. Pitch is added to determine height. Timbre is introduced to depict different colours. In a remarkably short time, blind people are able to ascertain immense awareness of their visual environments.

Significantly, Amedi added, brain imaging indicates that the part of the brain processing the information is identical, whether a sighted person is looking at something with their eyes or a blind person is “looking” at something using the auditory sensory-substitution process.

More information about Amedi’s work is online at brain.huji.ac.il.