Tag: Ilan Dinstein

Productive collaboration

The Azrieli National Centre for Autism and Neurodevelopment Research team includes, left to right, Dr. Gal Meiri, Prof. Hava Golan, Prof. Ilan Dinstein, Mazal Malka and Prof. Idan Menashe. Dinstein and Menashe will be in Vancouver in May to meet with colleagues from the University of British Columbia. (photo from azrielifoundation.org)

When the International Society for Autism Research convenes in Seattle April 30 for its annual conference, researchers from all over the world will be flying in to learn about and share the latest research on this multifactorial disorder. Two of them, Idan Menashe and Ilan Dinstein, who head up the Azrieli National Centre for Autism and Neurodevelopment Research (ANCAN) at Ben-Gurion University, will be coming from Israel. When the conference wraps up, they will be in Vancouver to continue a three-year collaboration with autism researchers at the University of British Columbia and Simon Fraser University, and meet with various people, including community members.

Menashe and Dinstein were part of a group – that included Dr. Tim Oberlander from UBC’s School of Population and Public Health and Grace Iarocci, director of SFU’s Autism and Developmental Disabilities Laboratory – that published a paper in 2023 on whether oxytocin is associated with an increased risk of autism in offspring.

“Oxytocin is a neuropeptide hormone that plays a key role in social behaviour, stress regulation and mental health,” begins the paper’s abstract. “Synthetic oxytocin administration is a common obstetrical practice and, importantly, previous research has suggested that intrapartum exposure may increase the risk of neurodevelopmental disorders, such as autism spectrum disorder.”

The study supported the conclusion that “induction of labour through oxytocin administration does not increase the risk of autism spectrum disorder in the child.” However, Menashe and Dinstein’s own studies in Israel found an association between autism and the use of general anesthesia during caesarean sections.

“Having a C-section with general anesthetic increases the risk of diagnoses of autism in offspring by 60% compared to natural birth,” Menashe told the Independent. Because general anesthesia in C-section is infrequently used, that risk is low, but consistent, he added.

Menashe, Dinstein, Oberlander and Iarocci are excited to reunite in Vancouver in May because they all have access to population health data that allows them to compare their results. Such comparisons are especially valuable given that autism rates are increasing the world over.

Menashe said the rate of autism is 2% in Israel and Canada, and more than 3% in the United States. “We know a big portion of this increase is due to increased awareness among parents and caregivers, but we don’t know if that explains everything,” he said. 

Autism is highly heterogeneous, he continued. “Every child is different and no two children present exactly the same autism symptoms. We believe the causes of autism are also very heterogeneous, and that’s what makes research so complicated, but also so interesting.”

Because of that heterogeneity, research requires collection of data from large populations. At the Azrieli National Foundation for Autism Research, Menashe and Dinstein work with nine clinical centres to collect data.

“A major advantage we have in Israel is our access to families’ medical records,” Menashe explained. “We ask families from those clinics to participate in genetic studies, through which we try to identify the genetic causes of autism.”

Menashe, Dinstein, Oberlander and Iarocci meet monthly by Zoom to discuss their findings. By collaborating, the four researchers can compare Israeli findings to those in British Columbia.

“The comparisons make our research more powerful,” Iarocci said. “They allow us to see what’s the same and what’s different cross-culturally.

“Our goal with autism is early identification, early diagnosis, and offering interventions that are effective,” she continued. “When we collaborate, we can compare very large data sets and, without those comparisons, you can’t really answer these questions meaningfully.” 

“We’ve had a very productive collaboration so far, and what makes it especially important is the cross-jurisdictional research we can do,” Oberlander said. “There are few jurisdictions in the world that can do this effectively, but Israel and BC are two of them. It’s a wonderful collaboration, a great model, and we’re looking forward to seeing them in Vancouver in May.”

While here, Menashe and Dinstein will participate in an invite-only parlour meeting on May 4. Those interested in attending should contact David Berson, executive director, BGU Canada, British Columbia & Alberta, at [email protected]. 

Lauren Kramer, an award-winning writer and editor, lives in Richmond

Complexities of autism

Israeli neuroscientist Dr. Ilan Dinstein was in Vancouver last month to talk about autism research. (photo by Adele Lewin)

Neuroscientist Dr. Ilan Dinstein was in Vancouver last month to share research and expand knowledge on best practices internationally. An associate professor of psychology and cognitive and brain sciences at Ben-Gurion University of the Negev (BGU), Dinstein is the director of the new National Autism Research Centre (NAC) in Israel.

David Berson, executive director of the Canadian Associates of BGU for British Columbia and Alberta, told the Independent: “CABGU was delighted to be a part of hosting Dr Ilan Dinstein in Metro Vancouver. This visit was spearheaded by Dr. Grace Iarocci, Dr. Elina Birmingham and Dr. Sam Doesburg from SFU [Simon Fraser University] and Dr. Tim Oberlander from B.C. Children’s Hospital.

“Ilan Dinstein is a true reflection of the pioneering spirit that is unique to the Negev region of Israel, where, over the past five years, clinicians from Soroka University Medical Centre and researchers from Ben-Gurion University of the Negev have organically come together to collaborate for the betterment of all of the residents with ASD [autism spectrum disorder] in the region.”

Dinstein spoke with the Independent about the new centre and the purpose of his visit to Canada.

“We started the centre five years ago, to try to understand different causes of autism,” he said. “Autism is not one disorder. There are different sub-types of autism, with different possible roots and risk factors. Some of those factors are biological or genetic; others might be environmental. For example, a premature birth might be a risk factor in the child developing autism. Or the age of the parents – a child of older parents might have a higher risk of autism diagnosis than if the same parents were younger. We at the centre are trying to discover how the combination of genetic and environmental issues affects autism development.”

According to Dinstein, one of the reasons for the creation of the centre was the way science is funded in Israel. “The funding usually comes for one specific question,” he explained, “but autism is a complex, systematic disorder and it needs many facets of study, measurement and research; it needs collaboration and sharing of information. At the centre, we are able to combine different fields of study with the clinical applications, as we work together with the Soroka medical centre.”

The scientists of the NAC study autistic patients from different multidisciplinary angles: neuroscience and cellular biology, language pathology and motor tracking, even facial features.

“The truly unique thing is that we do all our studies inside the hospital,” Dinstein said. “Parents come in with their children, usually when the children are about 3 years old and the parents and the children’s teachers notice the kids’ uncommon behavioural patterns. The diagnosis of autism usually takes four visits. During those visits, we work in collaboration with the doctors, measuring various characteristics of the child’s development to arrive at the right diagnosis.

“We also started a database of all our patients, so we have a centralized well of knowledge about how various biological, cultural and social factors might contribute to autism development.”

Of course, not all of the parents agree to have their child added to the database, but Dinstein said that their recruitment rate is about 80%.

After the diagnosis, the scientists participate in determining a personalized treatment program, based on their research. “Such a program might include teaching the children useful behavioural habits, helping them with language acquisition or providing occupational therapy,” explained Dinstein. “Some autistic kids are very agitated and certain motions, like spinning, might calm them down. Sometimes, autistic children need to learn basic skills: how to dress themselves or brush their teeth.”

Pharmaceuticals can also help children cope with autism, but Dinstein said that only about 10% of patients use medications.

At the NAC, the scientists don’t treat patients, but rather study and make recommendations, develop new technologies and new methods of dealing with the disorder. Working together with clinical professionals, they hope to contribute to a higher rate of success in treatment.

One of the most important aspects of Dinstein’s and his colleagues’ work is an annual follow-up on the patients in the database. Families are required to come back once a year after the initial diagnosis, so the service providers can see their progress, determine what worked and what didn’t, and adjust their recommendations accordingly.

“We are still in the process of enlarging this project,” said Dinstein. “We want to open other locations in Israel, make our database to cover the entire state of Israel.”

The centre’s autism research, in particular its database of patients with autism, inspired interest locally, from scientists and clinicians to families and service providers. The invitation for Dinstein to visit Vancouver came from a range of people.

“Your researchers want to create a similar database to ours, Canada-wide,” said Dinstein about his presentation at the Children’s Hospital. “I met with scientists from UBC [University of British Columbia] and SFU, even some from Victoria. I also met medical professionals, parents, some service providers and stakeholders. I see these meetings as the beginning of a close relationship between autism research in Israel and in Canada. There are similarities there, but there are differences, too. Both countries have different ethnic maps, cultural traditions and genetic variations. We all want to know how such diversity affects autism.”

Olga Livshin is a Vancouver freelance writer. She can be reached at [email protected].