In her lab at the Hebrew University of Jerusalem, Prof. Sigal Ben-Yehuda and her team have observed that bacteria can exchange molecules, genetic material and survival strategies through tiny structures called nanotubes. These findings suggest that, rather than acting independently, bacteria are capable of molecular communication.
This microbial interaction is at the heart of Ben-Yehuda’s research, pointing to a microscopic network built on exchange and cooperation. She will present this work in Vancouver April 29, as the featured speaker at the Dmitry Apel Memorial Lecture, hosted by the University of British Columbia.
Ben-Yehuda described herself as a scientist driven by questions. “I am fascinated by how bacteria make decisions, communicate and sense one another,” she told the Independent.
That interest has guided her career – from a PhD in microbiology at Tel Aviv University to postdoctoral research at Harvard. Since 2004, she has been a professor at the Hebrew University, where, two years ago, she became head of the department of microbiology and molecular genetics at the Institute for Medical Research Israel-Canada.
Ben-Yehuda’s research into bacterial communication did not begin with a specific hypothesis. “It began with a set of microscopy observations that raised the idea that bacteria can mysteriously share intracellular molecules,” she said. “That curiosity turned into a deeper investigation, which led to the identification of bacterial intercellular bridges that the group termed ‘nanotubes,’ that mediate this form of communication.”
Ben-Yehuda explained that these structures “allow bacteria to transfer molecules and DNA between cells – effectively creating a biological highway for the exchange of antibiotic resistance.”
This resistance develops when bacteria evolve to survive drugs that once killed them, posing a major challenge in treating infections. Ben-Yehuda’s findings could shape new approaches to combating infections by targeting the bacterial links rather than individual cells.
While centred on the microscopic world, Ben-Yehuda’s work speaks to something larger – an approach to science that begins with curiosity and unfolds through observation. This open-ended inquiry is exactly what the upcoming seminar seeks to celebrate.
The Dmitry Apel Memorial Seminar was created in memory of UBC PhD student Dr. Dmitry Apel, who passed away in 2013. His family, notably his mother, Dr. Maryana Apel, and sister, Dr. Sabrina Apel, sponsor the lecture that honours his devotion to pure science, which was driven by a curiosity about how the world works.
Prof. Yossef Av-Gay, a professor in the UBC Faculty of Medicine’s division of infectious diseases, who, among other things, also holds an adjunct professorship at the medical school of Ben-Gurion University of the Negev, invited Ben-Yehuda to speak.
“I thought that Sigal would be an inspiration for young scientists,” he said. “She discovered nanotubes – a great new discovery in microbiology. Having a strong microbiology department at UBC, focusing on similar fields as Sigal’s department at Hebrew University, I saw this as a chance to spark cross-continent collaborations. The Apel family has close ties to Israel, so it felt like a perfect fit and a great opportunity to bring Sigal to Dmitry’s memorial seminar.”
As a department head, Ben-Yehuda works to support early-career researchers.
“My main goal has been to support the younger faculty members,” she said. “I’m committed to helping them create strong research groups and establish themselves – and their labs – as leaders in their fields.
“As for my lab, my approach has been to encourage curiosity-driven research, which depends on the scientists and their progression. I encourage independence and creativity.”
Although this will be Ben-Yehuda’s second visit to Vancouver, it will be her first time speaking at UBC. Hosted by microbiologist Av-Gay, her visit will include meetings with faculty and colleagues, along with the hope of having time to explore the city and its surroundings.
As for her hope of what people will learn from her lecture, Ben-Yehuda said, “An important takeaway is that connection matters. Whether you’re a microbe or a human, being part of a community can enhance resilience and adaptability. Also, cooperation – far from being a soft or secondary trait – can be a powerful survival strategy. It reminds us that strength often comes not just from competing, but from collaborating, and highlights community strength.”
For more information on the Dmitry Apel Memorial Seminar and Ben-Yehuda’s talk, visit mbim.ubc.ca/events/dmitry-apel-memorial-seminar-2025.
Uriel Presman is a student at Queen’s University and serves as executive vice-president of external relations at Hillel Queen’s.