{"id":35061,"date":"2020-06-26T03:36:43","date_gmt":"2020-06-26T10:36:43","guid":{"rendered":"http:\/\/www.jewishindependent.ca\/?p=35061"},"modified":"2020-06-24T11:51:20","modified_gmt":"2020-06-24T18:51:20","slug":"studying-the-love-hormone","status":"publish","type":"post","link":"https:\/\/www.jewishindependent.ca\/index.php\/2020\/06\/26\/studying-the-love-hormone\/","title":{"rendered":"Studying the \u201clove hormone\u201d"},"content":{"rendered":"

Oxytocin, a peptide produced in the brain, may bring hearts together \u2013 or it can help induce aggression. (image from Weizmann Institute)<\/em><\/strong><\/span><\/p>\n

During the pandemic lockdown, as couples have been forced to spend days and weeks in each other\u2019s company, some have found their love renewed while others are on their way to divorce court. Oxytocin, a peptide produced in the brain, is complicated in that way: a neuromodulator, it may bring hearts together or it can help induce aggression. This conclusion arises from research led by Weizmann Institute of Science researchers in which mice living in semi-natural conditions had their oxytocin-producing brain cells manipulated in a precise manner. The findings, which were published in Neuron<\/em>, could shed new light on efforts to use oxytocin to treat a variety of psychiatric conditions, from social anxiety and autism to schizophrenia.<\/p>\n

Much of what we know about the actions of neuromodulators like oxytocin comes from behavioural studies of lab animals in standard lab conditions. These conditions are strictly controlled and artificial, in part so that researchers can limit the number of variables affecting behaviour. But a number of recent studies suggest that the actions of a mouse in a semi-natural environment can teach us much more about natural behaviour, especially when we mean to apply those findings to humans.<\/p>\n

Prof. Alon Chen\u2019s lab group in the institute\u2019s neurobiology department have created an experimental setup that enables them to observe mice in something approaching their natural living conditions \u2013 an environment enriched with stimuli they can explore \u2013 and their activity is monitored day and night with cameras and analyzed computationally. The present study, which has been ongoing for the past eight years, was led by research students Sergey Anpilov and Noa Eren, and staff scientist Dr. Yair Shemesh in Chen\u2019s lab group.<\/p>\n

The innovation in this experiment was to incorporate optogenetics \u2013 a method that enables researchers to turn specific neurons in the brain on or off using light. To create an optogenetic setup that would enable the team to study mice that were behaving naturally, the group developed a compact, lightweight, wireless device with which the scientists could activate nerve cells by remote control. With the help of optogenetics expert Prof. Ofer Yizhar of the same department, the group introduced a protein previously developed by Yizhar into the oxytocin-producing brain cells in the mice. When light from the wireless device touched those neurons, they became more sensitized to input from the other brain cells in their network.<\/p>\n

\u201cOur first goal,\u201d said Anpilov, \u201cwas to reach that \u2018sweet spot\u2019 of experimental setups in which we track behaviour in a natural environment, without relinquishing the ability to ask pointed scientific questions about brain functions.\u201d<\/p>\n

Shemesh added that \u201cthe classical experimental setup is not only lacking in stimuli, the measurements tend to span mere minutes, while we had the capacity to track social dynamics in a group over the course of days.\u201d<\/p>\n

Delving into the role of oxytocin was sort of a test drive for the experimental system. It had been believed that this hormone mediates pro-social behaviour. But findings have been conflicting, and some have proposed another hypothesis, termed \u201csocial salience,\u201d stating that oxytocin might be involved in amplifying the perception of diverse social cues, which could then result in pro-social or antagonistic behaviours, depending on such factors as individual character and the environment.<\/p>\n

To test the social salience hypothesis, the team used mice in which they could gently activate the oxytocin-producing cells in the hypothalamus, placing them first in the enriched, semi-natural lab environments. To compare, they repeated the experiment with mice placed in the standard, sterile lab setups.<\/p>\n

In the semi-natural environment, the mice at first displayed heightened interest in one another, but this was soon accompanied by a rise in aggressive behaviour. In contrast, increasing oxytocin production in the mice in classical lab conditions resulted in reduced aggression.<\/p>\n

\u201cIn an all-male, natural social setting, we would expect to see belligerent behaviour as they compete for territory or food,\u201d said Anpilov. \u201cThat is, the social conditions are conducive to competition and aggression. In the standard lab setup, a different social situation leads to a different effect for the oxytocin.\u201d<\/p>\n

If the \u201clove hormone\u201d is more likely a \u201csocial hormone,\u201d what does that mean for its pharmaceutical applications?<\/p>\n

\u201cOxytocin is involved, as previous experiments have shown, in such social behaviours as making eye contact or feelings of closeness,\u201d said Eren, \u201cbut our work shows it does not improve sociability across the board. Its effects depend on both context and personality.\u201d<\/p>\n

This implies that, if oxytocin is to be used therapeutically, a much more nuanced view is needed in research: \u201cIf we want to understand the complexities of behaviour, we need to study behaviour in a complex environment. Only then can we begin to translate our findings to human behaviour,\u201d she said.<\/p>\n

Participating in this research were scientists at the Max Planck Institute for Psychiatry in Munich, including research students Asaf Benjamin and Stoyo Karamihalev, staff scientist Dr. Julien Dine and postdoctoral fellow Dr. Oren Forkosh of the Chen lab; Prof. Shlomo Wagner and postdoctoral fellow Dr. Hala Harony-Nicolas of Haifa University; Prof. Inga Neumann and research student Vinicius Oliveira of Regensburg University, Germany; and electrical engineer Avi Dagan.<\/p>\n","protected":false},"excerpt":{"rendered":"

Oxytocin, a peptide produced in the brain, may bring hearts together \u2013 or it can help induce aggression. (image from Weizmann Institute) During the pandemic lockdown, as couples have been forced to spend days and weeks in each other\u2019s company, some have found their love renewed while others are on their way to divorce court. […]<\/p>\n","protected":false},"author":2,"featured_media":35062,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4329],"tags":[9985,2864,9984,2225,4381],"class_list":["post-35061","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-israel","tag-alon-chen","tag-health","tag-oxytocin","tag-science","tag-weizmann-institute"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":8}},"_links":{"self":[{"href":"https:\/\/www.jewishindependent.ca\/index.php\/wp-json\/wp\/v2\/posts\/35061","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jewishindependent.ca\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jewishindependent.ca\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jewishindependent.ca\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jewishindependent.ca\/index.php\/wp-json\/wp\/v2\/comments?post=35061"}],"version-history":[{"count":0,"href":"https:\/\/www.jewishindependent.ca\/index.php\/wp-json\/wp\/v2\/posts\/35061\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.jewishindependent.ca\/index.php\/wp-json\/wp\/v2\/media\/35062"}],"wp:attachment":[{"href":"https:\/\/www.jewishindependent.ca\/index.php\/wp-json\/wp\/v2\/media?parent=35061"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jewishindependent.ca\/index.php\/wp-json\/wp\/v2\/categories?post=35061"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jewishindependent.ca\/index.php\/wp-json\/wp\/v2\/tags?post=35061"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}